This systematic literature review explores how AI interacts with mindfulness practices in the workplace, particularly within the context of Human Resource Management (HRM). Guided by the POWER framework—Planning, Organization, Writing, Evidence, and Review—this study systematically analysed 40 high-quality research papers selected from an initial pool of 25,700 articles identified across major academic databases. Inclusion criteria focused on peer-reviewed studies published between 2012 and 2025 that examined the role of AI and mindfulness in employee well-being, stress mitigation, technostress, and workplace performance. The review reveals a growing recognition of AI’s dual role as both a potential stressor and a facilitator of mental well-being when combined with mindfulness interventions. Key thematic findings include AI-assisted mindfulness tools, the moderating role of mindfulness in technostress, and the strategic integration of mindful technologies in HRM. The paper concludes with a research agenda highlighting the need for more empirical studies, theoretical models, and cross-disciplinary approaches to align AI innovation with human-centred well-being at work