The study conducted an analysis of the factors influencing entrepreneurial activities of businesses in Viet Nam with 400 questionnaires distributed and 386 collected. The results revealed 5 factors with 24 observed variables using Exploratory Factor Analysis (EFA) and multivariate regression methods. This demonstrated that all 5 factors have an impact on the entrepreneurial activities of businesses in Viet Nam. They are Human Capital; Local Culture and Business Culture; Access to Finance; Relationships between organizations in the startup ecosystem and Business Environment. Among these, the Business Environment, Access to Finance and Human Capital factors were found to have the strongest impact on entrepreneurial activities of businesses in Vietnam