This study investigates the relationships between emotional intelligence ability (EI-Ability), psychological well-being (SPWB), workplace well-being (SWWB), and salesperson work en-gagement (SWE) within Germany’s pharmaceutical B2B sector. Grounded in the Job De-mands-Resources (JD-R) theory, the study further explores the mediating roles of SPWB and SWWB in the EI–SWE linkage. A quantitative, cross-sectional survey was administered to 375 salespersons employed in pharmaceutical firms across North Rhine-Westphalia, with 340 valid responses obtained via simple random sampling. The data were analyzed using Structural Equation Modeling (PLS-SEM). The findings indicate that EI-Ability positively and signifi-cantly affects SPWB, SWWB, and SWE. Both SPWB and SWWB also positively influence SWE and partially mediate the relationship between EI-Ability and SWE. Notably, EI-Ability accounts for 61% of the variance in SPWB and 57% in SWWB, while the combined predictors explain 71% of the variance in SWE. The study offers critical implications for practitioners and poli-cymakers aiming to enhance engagement in similar high-pressure organizational contexts.